Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
3. 《聚焦》(Spotlight)，导演：汤姆·麦卡锡(Tom McCarthy)。
A colourful and exhaustive biography of Alan Greenspan, the former chairman of the US Federal Reserve, is this year’s Financial Times and McKinsey Business Book of the Year.
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
“We sincerely apologize to Moonlight, La La Land, Warren Beatty, Faye Dunaway, and Oscar viewers for the error that was made during the award announcement for Best Picture. The presenters had mistakenly been given the wrong category envelope and when discovered, was immediately corrected.”
The media are annoying, we get that, Your Royal Highness, but there may have been more dignified ways for you (and the establishment you represent) to air your concerns.
Trends and targets in antiviral phototherapy
“Climate change is perhaps the major challenge of our generation,” said Michael H. Freilich, director of earth sciences at NASA, one of the agencies that track global temperatures.
Boston Consulting Group could also be poised to make a change given its managing partner, Richard Lesser, is due to come to the end of his second term in October. His future is unclear, however, as the firm declined to comment on its election process or how many terms its leader can serve.
"I'm always amazed at how many people tell their co-workers about their job search," Kay says. "That's one of the worst things you can do." Ideally, you wouldn't tell any co-workers, but you may have to if you want them to serve as references. In that case, Kay says, "you need to pick people who you really trust, who don't have a hidden agenda and who won't let it slip."
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
As he scanned the Internet for knowledge, D'Aloisio decided that what he really needed was a better way to determine, at a glance, what was worth reading. He envisioned a summarization tool that used language theory to give a meaningful synopsis in fewer than 400 characters.
Novel biosensing methodologies for ultrasensitive detection of viruses
China’s foreign exchange reserves posted their third-largest monthly decline on record last month, central bank data showed yesterday, renewing worries about capital outflows after reserves had appeared to stabilise.
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
You might think Hawaiian has it relatively easy, since its flights rarely have to contend with the kind of challenging weather conditions found on the mainland. Hawaiian perennially rates high in on-time performance rankings, topping the most recent DOT list i n September. It recently announced it will branch well beyond its island home with non-stop service to Beijing.
ACE2 as a potential therapeutic target for pandemic COVID-19
法国兴业银行(Societe Generale)国际策略师基特?朱克斯(Kit Juckes)说，过去30年破灭的三个世界级金融大泡沫背后，都是“美联储(Fed)太久时间将政策利率维持在名义经济增长率之下”。
Social network Facebook Inc., e-commerce giant Amazon and toy company Lego were the top-growing brands.
Diagnostic technologies for COVID-19: a review
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
He did several makeup tests to get the look that would so dramatically change Mr. Carell. “We were literally creating a new human being,” Mr. Corso said.
Whether or not any sort of BlackBerry-Samsung deal actually happens, the development highlights next wave of innovation (and litigation) in mobile technology: one centered on access control methods and containing corporate breachesin an increasingly mobile world.
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Moving away from fossil fuels to renewable energy is surely the most important engineering and scientific challenge of our age.
Many analysts may be surprised at the suggestion that they have underplayed the Fed. The two factors most often cited in relation to EM assets these days are the Fed and China, and the risk that they will deliver a negative shock.
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Antiviral drug discovery: broad-spectrum drugs from nature
Comic skit “Give Hand So That I Won’t Be Lonely”(Feng Gong, Guo Donglin and Yan Xuejing)
My hunch is that this draft will look pretty good by March and will be much better than last year's, which was one of the most underwhelming in recent memory. New Orleans and Washington both need some direction, and soon.
Influenza neuraminidase: A druggable target for natural products
Liu Fei was also a half-brother of the Emperor Wu of Han who ruled from 141BC to 97BC.
Bank of China posted earnings per share of Rmb0.56, down from Rmb0.61, and a pre-tax dividend per share of Rmb0.175, down from Rmb0.19 last year.
Be prepared to save his life on numerous occasions.
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
Lenovo CEO Yang Yuanqing
Actuaries put a financial value on risk for instance, the chances of a hurricane destroying a beachfront home or the long-term liabilities of a pension system. In a world awash with risks of the natural and manmade variety, the profession is booming, says Tony Lee, publisher of CareerCast.com. In addition, he says, 'there's a severe shortage of actuaries, ' so wages are rising. (The median salary for actuaries in 2010 was $87, 650, according to the Labor Department.)
The role of biosensors in the detection of emerging infectious diseases
Quantitative determination of mechanical stability in the novel coronavirus spike protein
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
Portugal's achievement gives governments and energy companies a tangible example of how it can and does work, and why they should be investing in solar, wind, wave and other renewable technologies now.
在接下来几年里，大型住宅楼盘必须遵守第87号本地法(Local Law 87)——该法要求楼盘审核能源使用量，并保持系统以最高效率运行。住宅楼是纽约市最大的温室气体排放源，其排放量占总量的37%。“能源是一大热门话题。楼盘怎样提高能源效率？”管理着超过500处房产的FirstService Residential New York的总裁丹·沃泽尔(Dan Wurtzel)说，“如果运营预算的三分之一来自能源耗费，而现在你可以降低这块成本，那么上涨维护费的压力就减轻了。”
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
gala＝milk牛奶，milky way＝银河系以xy结尾的只有4个单词，xy表示交织在一起，象坐标线一样，银河系也象星星交织在一起。参：neodoxy（n 新学说；新见解）；orthodoxy（adj 正统的）；heterodoxy（n 非正统；异说）
That Apple could launch a 2,000 yuan ($330) iPhone mini and be competitive with flagship products from Lenovo, Huawei, ZTE and Coolpad.
乔布斯在苹果博览会上展示iPod mini ，2004年1月6日，旧金山
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Inhibition of SARS coronavirus helicase by bismuth complexes
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
“The course was delivered by top-notch practitioners,” says one HEC Paris graduate. “The programme is perfectly designed for young professionals having limited finance experience and allows them to be immediately operational upon graduation.”
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
The cemetery was first found in July 2007and was excavated by the Xinjiang Institute of Cultural Relics and Archaeology,with assistance from local authorities. The research team, led by Zhiyong Yu,director of the Xinjiang Archaeological Institute, published the findings in Chinese in the journal Wenwu. The article was recently translated into Englishand published in the journal Chinese Cultural Relics.
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
库什纳回忆道，我当时被他深深折服了。他到新闻集团去见默多克时，我与他有了第一次接触，当时我被一同叫去提提意见。达洛伊西奥在会上描述了他想要实现的远景。他帮助默多克加深了对一些事物的见解。达洛伊西奥在台上的优异表现，加上背后李嘉诚的雄厚财力，为Summly招来了包括艾什顿?库奇(Ashton Kutcher)、小野洋子(Yoko Ono)、史蒂芬?弗莱(Stephen Fry)等许多人的捐赠。
Rouslan Krechetnikov和Hans Mayer对液体的溅出现象进行了研究。他们考察的课题是：人们在端着咖啡杯走动时咖啡的溅出情况，给你个提示吧，在你走到第七步至第十步之间，咖啡最容易溅出。
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
《欢迎来到我的世界》(Welcome to Me)，导演：舍拉·皮文(Shira Piven)。
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
The 2018 Academic Ranking of World Universities released last Wednesday by Shanghai Ranking Consultancy reveals that 62 research universities in China have made their list of the world's top 500 universities.
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
《江城警事》(Battle Creek)，CBS，3月1日播出。重磅剧就是会带来这样的改变。文斯·吉利根在十几年前就为这部亦敌亦友的警探搭档剧写好了试播集剧本，当时他还不是《绝命毒师》与《风骚律师》的主创。如今它终于被CBS拍成13集连续剧了。《法律与秩序：特殊受害者》(Law & Order: SVU)和《我为喜剧狂》(30 Rock)的主演在剧中饰演一个当地警探，《拉斯维加斯》(Las Vegas)主演乔希·杜哈明(Josh Duhamel)饰演一个老练的联邦调查局探员，两人在密西根州巴托溪的塞里尔城共事，相处得很不自在。
贝克(Beck)，《说再见》(Say Goodbye)， Capito
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
But back to TextPride. Wray and O’Brien saw the way users eagerly engaged with their branded emojis, and believed advertisers appreciated the convenience of using one vendor to get many different messaging apps. But they realized that that was only half of the business. For certain established brands like sports teams, people will pay for stickers. But other, unknown brands would pay just to be included.
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
By March, there's a real chance two or three of these prospects stick out as franchise players.
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
Traders heading for the exits: 'Unsustainable trends can survive much longer than most people anticipate, but they do end when their 'time is up, at the culmination of their time cycles.' They analyzed more than 20 cycles: 'Nearly unanimously point to tectonic shifts in the months and years ahead.'
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
Hello, I'm Severn Suzuki speaking for E.C.O. - The Environmental Children's Organisation. 大家好，我是Severn Suzuki，我代表儿童环境组织来此演讲。
CONTACT: Kathy Michalove, Seaboard Properties, (860) 535-8364; seaboardpropertiesre.com
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
With the right tools in place, you’ll find yourself more productive and efficient.
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
This post is in partnership with Time. The article below was originally published at Time.com
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
Another indicator of bitcoin’s momentum is the number of mainstream businesses that accept it. In 2014, Microsoft MSFT -0.84% , PayPal, Dell, and Dish Network DISH 2.24% , among many others, announced they would accept bitcoin as payment for a range of products. Those companies joined companies such as Target (which accepts Gyft, which can be purchased with bitcoin), Overstock.com, and WordPress. Even the publisher of Fortune, Time Inc. TIME -0.40% ,began accepting the cryptocurrency for magazine subscriptions. Yahoo YHOO -1.02% also added bitcoin to its Yahoo Finance tracking site last year, lending the currency additional legitimacy, and Google Finance GOOG -1.30% quickly followed suit. “Adoption of bitcoin is becoming more commonplace, and we feel it is relevant to our industry and to our users,” a Yahoo spokesperson told CoinDesk. Don’t be at all surprised if Yahoo soon goes even bigger on bitcoin—whether by acquiring a bitcoin startup or some other announcement—as part of CEO Marissa Mayer’s ongoing effort to make the stalling search giant more hip.
“I saw a woman die and I saw the president of the United States refuse to unequivocally condemn the people who killed her.”
A modular microarray imaging system for highly specific COVID-19 antibody testing
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
200911/88512.shtmlA 1936 Nobel Peace Prize discovered at a South American pawn shop has been sold at auction in Baltimore for $1.16 million.
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
Just like you don't need a smart bottle opener, you don't need a smart wine bottle. The Kuvee is a bottle of wine with a screen on it that helps you learn about your favorite wines. There's really nothing more to it, aside that it keeps track of the wines you've tasted and can keep bottles fresh for up to 30 days.
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
The mattress comes with sensors inside the bed that can detect pressure and send messages to the app, which spares no details. The app not only detects movement on the bed, but also records the intensity and speed at which people are getting it on.
A facile assay for rapid detection of COVID-19 antibodies
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
William Leung, portfolio manager at Cohen & Steers, the US investment house with $4bn of assets exposed to Asia, agrees. He argues that speculative investment will be driven out of the market as prices fall. He adds that a trend in the industry towards alternative investments should mean that the price of real estate investment trusts rises even if the value of underlying assets grow more slowly. “We don’t think this correction will be so sharp,” he says.
Issued by the Institute of Social Security Research, Ministry of Human Resources and Social Security, the report shows that the return rate of enterprise employees' pension insurance fund reached 3.1 percent, the highest in seven years.
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
After working for half a year, the average monthly income for 2014 graduates is RMB3,487, a significant increase from RMB3,250 in 2013 and RMB3,048 in 2012.
今年，我最喜欢的人物报道可能是Kiki Zhao对中国目前读者最多的诗人之一余秀华激动人心的描写。余秀华是一个了不起的人。她患有脑瘫，过去41年里大部分时间生活在农村，在一张矮桌子上写作。高中没毕业的她说自己“在能读它们（名著）之前，我就知道如何写作了”。现在，她受邀前往斯坦福大学等地，她不愿被比作艾米丽·迪金森(Emily Dickinson)。
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Snap, however, has sunk to about $15 after initially rallying from its IPO price of $17 in March, damping some expectation of further activity involving so-called decacorns, tech companies that have achieved valuations of $10bn or more through private funding.
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
3. Economy is already crashing, GDP will get even worse in 2014-2016
According to the new report, over the past 20 years India has been the leading user of anti-dumping cases, filing 767, or 15 per cent, of the 4,990 initiated between 1995 and 2015. The US accounted for 570 while the EU registered 480.
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Anti-HIV drug repurposing against SARS-CoV-2
Length-scale dependence of protein hydration-shell density
When M·A·S·H first aired, the characters of Hawkeye and Trapper were meant to be equally sized roles. It was with that understanding that Wayne Rogers agreed to take the role of Trapper John. However, as Alan Alda began to make changes to the characters and have more influence on the direction of the show, Hawkeye began to seriously eclipse Trapper.
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
But economists generally expect the momentum of the recent past to resume and continue once storm distortions abate. The 45 economists who responded to The Wall Street Journal's latest monthly forecasting survey saw the jobless rate falling to 7.8% by next June and 7.5% by the end of 2013. Some say job growth could accelerate from its slow pace. 'I think businesses are going to have to hire,' said Bob Baur, an economist with Principal Global Investors.[qh]
Rolling ahead with a team that's .500 through November isn't at all tanking — this is seriously a potential playoff team — but it's the same type of conversation the rebuilding squads are having. Leverage assets and playing time to win more now, or stay focused on sustainability?
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
‘Veep’ “House of Cards,” the Netflix phenomenon, showed its weaknesses this year, but HBO’s “Veep,” the other most cynical show about Washington, got stronger in its third season. The scene in a restroom in which Selina (Julia Louis-Dreyfus) and her assistant, Gary (Tony Hale) discover that she is going to become president and dissolve into uncontrollable laughter was one of the great comic moments of 2014.
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Americans are celebrating Columbus Day Monday.Columbus Day is a federal holiday observed on the second Monday in October, marking the anniversary of the arrival of Christopher Columbus to the Americas. Columbus, an Italian explorer sailing under the Spanish flag, led four expeditions to the New World, but never accomplished his original goal -- to find a western ocean route to Asia. Instead, Columbus ushered in a new era in world history by opening up the Americas to exploration.