Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Good luck, good health, hood cheer. I wish you a happy New Year.
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
"By the end of next year we will be at the point where the unemployment rate is between 5% and 5.5%, and it will truly feel legitimate," Faucher said.
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
‘The Mindy Project’ It doesn’t matter that Mindy Kaling’s comedy on Fox is in its third season and still not a hit, because it keeps improving with age. It has grown from a one-comedian showcase into a very funny ensemble effort, thanks in part to the addition of Adam Pally in Season 2 and jokes about Ms. Kaling’s alma mater, Dartmouth.
Trends and targets in antiviral phototherapy
The ranking measures the quality and breadth of the schools’ postgraduate programmes. Schools must take part in all four rankings to be eligible for a full score. LBS rose from third last year by participating in all four rankings for the first time.
Swyft有50家短信应用合作伙伴，包括Kakao Talk, Facebook Messenger, BlackBerry Messenger和 Line。这种合作让这家只有11个人的小公司能接触到25亿注册用户。随着利用短信应用赚钱的办法不断演化，这家年轻的创业公司已探索出一条可让各大品牌挤进人们聊天领域的生财之道。（财富中文网）
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Although Guo has not given any timetable for her retirement, her announcement at December's East Asian Games about a possible one-year hiatus is a clear enough signal. From all evidence, her relationship with Fok seems to have entered another stage. Unless they truly believe that the Chinese lunar calendar warns against a "widow's year" in 2010, we might well see Miss Guo become Mrs Fok.
Novel biosensing methodologies for ultrasensitive detection of viruses
At present, 15 Chinese cities allow a 72-hour visa-free entry for nationals of certain countries. Shanghai, Jiangsu and Zhejiang offer 144-hour visa-free stays for international transit passengers from certain countries.
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
2. Google Docs
ACE2 as a potential therapeutic target for pandemic COVID-19
Diagnostic technologies for COVID-19: a review
China will remain an important engine for world growth amid sluggish global economic recovery.
Ms Lewis urged people to contact family, neighbours or an animal shelter if they were no longer able to care for their pets.
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
'It doesn't have carbs, fat or protein so it won't provide calories, unlike sprinkles which have sugar. It's mostly for decoration. It's tasteless,' said registered dietician Alix Turoff.
A private reading on China's manufacturing sector suggests the slowdown continued last month but that conditions had not worsened as much as in October. The Caixin-sponsored preliminary manufacturing PMI was 48.6 in November, versus expectations of 48.3. It had been 48.3 in October.
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
在牵手其他领域的精英这一点上，谷歌并非独家。今年早些时候，英特尔（Intel）便宣布与美国时尚设计师协会（Council of Fashion Designers of America，CFDA）和奢侈品零售商Opening Ceremony合作，设计智能手镯。时尚品牌汤丽柏琦（Tory Burch）也与Fitbit携手设计了与可穿戴技术创业公司Misfit Wearables的无线运动跟踪器Shine Tracker类似的吊坠与手镯。而苹果（Apple）也发掘了各行各业的人才，包括博柏利（Burberry）前任首席执行官安吉拉o阿伦德茨（担任零售主管）、伊夫o圣o洛朗（Yves Saint Laurent）前任首席执行官保罗o丹尼佛以及耐克（Nike）的前任设计主管本o谢弗。
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Antiviral drug discovery: broad-spectrum drugs from nature
We will continue to encourage people to start businesses and make innovations.
The EU’s Americas gambits
Just because the job market is tough doesn't mean it's impossible. "You have to work harder at the job search," Challenger said.
Influenza neuraminidase: A druggable target for natural products
Make sure you've got a good plan for seeing that your children are cared for when you're scheduled to be in class, and when you need to study. It really is possible to raise children while you're going to school. People do it every day.
Subdivided flats smaller than 100 square feet (9 square meters) can rent for $385 in the Asian city.
斯特罗恩表示，他认为IP-BOX运用了和FBI没有经过苹果公司的帮助而破解塞义德·法鲁克iPhone 5c相同的技术。现在FBI已经开始向其他执法部门提供帮助解锁iPhone，iPad或者iPod Touch的方法。苹果方面正在积极寻找FBI是如何破解iPhone的，并将推出软件更新来关闭这些漏洞。
节目37 相声《东西南北大拜年》，赵炎 逗笑 逗乐 大新等
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
Tracey and Viv Williams, a British couple, dressed as the green cartoon ogres from Shrek at their wedding held recently. Tracy, 33, made a lovely Princess Fion
The ground-breaking discoveries in physics, have ignited a firestorm of research, and it’s only a matter of time before their research leads to advances as unimaginable to us now as lasers and computer chips were a hundred years ago, Laura H. Greene, president-elect of the American Physical Society told The New York Times.
The role of biosensors in the detection of emerging infectious diseases
Quantitative determination of mechanical stability in the novel coronavirus spike protein
Similar to quick LinkedIn overhauling, Foss says employers will likely notice if you abruptly go from tweeting cat GIFs and "Game of Thrones" spoilers to posting thoughtful, industry-focused content and participating in job-search Twitter chats. These are generally good moves for your job search, but bad ones for keeping it under wraps, so again, take it slow。
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
Spending on medicines in "pharmergingmarkets" will rise more than 50 percent over the next five years, ThePharma Letter said, citing IMS.
In global health, 2016 will be remembered as the year a little known virus made a major impact. It felt strangely familiar, but this time it wasn't Ebola making headlines around the world, it was Zika - a mosquito-borne virus being linked to a huge spike in the number of babies in Brazil born with brain defects.
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
Goldie Blox是一家玩具公司，使命是重新定义玩具商店中的“粉红走道”。在科学、技术、工程和数学（STEM）教育和职业领域，男性数量要大大多于女性，大部分女孩往往在八岁前就对这些领域失去了兴趣。Goldie Blox所设计的玩具则通过吸引女孩发展强大的口头及故事讲述能力的方式——同时仍提供机会来发展日后可转化成对工程学兴趣的技能——来鼓励和启发未来的工程师们。说到机会，一家玩具初创企业如何能在和一开始就统治着玩具行业的大公司的抗衡中脱颖而出呢？Goldie Blox走出了明智的一步：最近，该公司发布了一段视频，采用了Beastie Boys的歌曲《女孩们》（Girls）做背景音乐，该视频得到了病毒式传播。尽管这段视频最终被撤下，但Goldie Blox在提高公众对让更多女性和女孩对STEM产生兴趣——以及对Goldie Blox玩具——的认知上，做了一份相当不错的工作。
在排名靠前的学校中，英国华威商学院(Warwick Business School)排名提升最大，从第16位提升至第9名。整体而言，上海交通大学(Shanghai JiaoTong University)的上海高级金融学院(Shanghai Advanced Institute of Finance)排名提升最大，从第28位提升至第14位。
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
President Barack Obama won re-election to a second term in the White House on Tuesday, television networks projected, beating Republican challenger Mitt Romney after a long and bitter campaign。
Inhibition of SARS coronavirus helicase by bismuth complexes
China’s foreign exchange reserves posted their third-largest monthly decline on record last month, central bank data showed yesterday, renewing worries about capital outflows after reserves had appeared to stabilise.
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
Movie buffs will soon be able to celebrate with a visual feast at the Beijing International Film Festival, where nearly 500 high quality films will be shown.
‘Law & Order: SVU’ This NBC ripped-from-the-soap-opera perils of Olivia (Mariska Hargitay) — psychopath rapist-stalker, tortured love affair, new baby — that took up so much air last season finally died down, and this season, the show’s 16th, the detectives got back to sex crimes à clef, including a Ray Rice-inspired episode about a star sportscaster who was seen on a surveillance camera punching the lights out of his wife.
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
The data showed that Samsung took the top spot, followed by Apple in second place. Even so, the shipments of the two top tech giants declined respectively by 3 percent and 7 percent, demonstrating decreased global market shares.
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Yet there are similarities between the demagogic elements of the Brexit campaign and the rise of Mr Trump.
adj. 反对的，敌对的 v. 和 ... 起冲突，反抗
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
Housing advocates worry that if rezoning is not done carefully, communities could quickly gentrify. “Look at what happened in Williamsburg,” said Harvey Epstein, the director of the community development project at the Urban Justice Center, referring to price escalations. “I don’t know why it wouldn’t happen in East New York or the Bronx or in Flushing.”
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
Exports to both South Korea and Asean countries fell by about 3 per cent, however, while those to re-exporter Hong Kong dropped by more than 16 per cent.
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
马修?麦康纳(Matthew McConaughey)和贾里德?莱托(Jared Leto) 均凭在剧情片《达拉斯买家俱乐部》(Dallas Buyers Club)中的真实演绎荣获金球奖，该片讲述了一群德克萨斯人向艾滋病病毒发起勇敢抗争的故事。获九次金球奖提名的莱昂纳多?迪卡普里奥(Leonardo DiCaprio)因在《华尔街之狼》(The Wolf of Wall Street)的出色表现第二次摘得最佳男演员桂冠。他在发表获奖感言时感谢了影片导演马丁?斯科塞斯(Martin Scorsese)对他的指导（该片是两人第五次合作），并感谢他“允许自己跟着他拍下了这部电影”。
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
3. Piggyback Rider
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
这里有一些散步和骑行的小径可通往其他的湖滨社区以及市中心，骑车去市中心15分钟可达，开车10分钟。附近有步行者艺术中心(Walker Art Center)和几座博物馆。冬天湖上很多人玩冰球和滑冰运动；夏天则流行划独木舟、游泳和钓鱼。
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Remedy: The tricky aspect of this regret is that it’s typically rooted in hindsight. Only after you’ve left the job and have moved on to something better, do you start beating yourself up for not making the leap sooner, even if it hadn’t been practical or possible. What you can do is to identify the factors that kept you in your former position as red flags to be aware of in the future and work to line up supports that will allow you to more quickly capitalize on other opportunities as they may present themselves. This could include reviewing and updating your resume with new accomplishments on a monthly or quarterly basis, keeping your LinkedIn account current, building up a contingency fund to allow you to feel less tethered to your current pay check and staying in the loop on industry news and gossip to be aware of where your skills and experience could be of value.
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Take multiple measures to cut costs.
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
But pop's wider world also offered a lot of pleasures from artists all over the spectrum, such as the 20th century legends like Blondie and Tori Amos, and upstarts like Dua Lipa and Girl Ray.
“Given the unfavourable reaction to the August depreciation, we think any further depreciation will not take place soon,” said Louis Kuijs, an economist at Oxford Economics based in Hong Kong. “In our view the October trade data keep pressure on [the government] for more domestic easing.”
Unlike MBAs, masters in management are targeted at those at the beginning of their career.
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
7. The 2012 Ig Nobel Physics Prize
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
The requirements come from one of two newly issued regulations over the taxi and online ride-hailing services by China's transportation authority. The regulations will take effect in October and November respectively.
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
China has fully complied with UN resolutions on the denuclearization of the Korean Peninsula, and is a staunch supporter of upholding the international nuclear non-proliferation regime.
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
As well as dancing, she has her eye on singing and acting - she has already acted in the TV shows Drop Dead Diva and Austin & Ally.
A modular microarray imaging system for highly specific COVID-19 antibody testing
“If you were going to be betting, you would bet its going to be warmer than 2015,” said Mr Karl.
The appointment of Inga Beale to run Lloyds of London and of Mary Barra to run General Motors marked an encouraging end to 2013. Progress for women in the coming year will continue to be too little and too slow, but you should expect to see women in positions of power and influence everywhere. Even Japan is starting to try to get women into work.
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
In this ranking of 90 European business schools, Insead in France leads the field for full-time and EMBA programmes, while the University of St Gallen in Switzerland is top for MiM. Iese of Spain and IMD of Switzerland were ranked number one for customised and open-enrolment executive education programmes respectively.
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
In 2017, his 14th season in the league, LeBron James averaged a career high in assists and rebounds. In the first two months of 2017-18, he's averaging a career high in 3-point percentage, but that's been talked about and dissected; it's been written about extensively.
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
In short, some New Yorkers dislike their neighbors almost as much as they do their landlords. Co-op and condominium boards beware: You do not fare much better.
库什纳回忆道，我当时被他深深折服了。他到新闻集团去见默多克时，我与他有了第一次接触，当时我被一同叫去提提意见。达洛伊西奥在会上描述了他想要实现的远景。他帮助默多克加深了对一些事物的见解。达洛伊西奥在台上的优异表现，加上背后李嘉诚的雄厚财力，为Summly招来了包括艾什顿?库奇(Ashton Kutcher)、小野洋子(Yoko Ono)、史蒂芬?弗莱(Stephen Fry)等许多人的捐赠。
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
o Outside events can intrude.Consumer Reports, which raved about the Model S, reported a few “quirks” recently that included door handles that failed to activate and a center touch screen that went blank, blocking access to most of the car’s functions. Edmunds.com has had trouble with its Model S too. More reports like that will dent Tesla’s heretofore shining reputation.
But nearly two-thirds (65 percent) of white evangelical Protestants say they think the storms are evidence of the "end times" as predicted by the Bible.
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
No. One way it could play out: after a tentative start involving lots of trading stops, bitcoin futures will slowly begin to attract institutional money. Commodity Futures Trading Commission positioning data will reflect the extraordinary long bias that exists for the product among money managers. As the huge cost of rolling futures positions becomes self-evident, longs will complain ever more loudly about routine divergences around settlement time. Just as a senate hearing is being scheduled to investigate potential manipulation of the market, futures prices will fall below spot, initiating a sell-off.
A facile assay for rapid detection of COVID-19 antibodies
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
位居榜单第三的是史蒂夫·卡瑞尔（Steve Carell）。《卑鄙的我2》（Despicable Me 2）在今年大获成功，斩获票房9.19亿美元。该电影系列累计已取得14亿美元的全球票房，该系列第三部《小黄人》（Minions）也即将上映。卡瑞尔今年还出演了小制作独立影片《迷途知返》（The Way Way Back）和《超级魔术师》（The Incredible Burt Wonderstone）。后一部影片的票房虽未能赚回制作成本，但是我们这里只关注票房收入——该部影片为卡瑞尔2013年的电影票房收入又添2,250万美元。
Despite our global economy, only 20 percent of Americans speak another language. Sixty Vocab is aiming to change that with it’s online foreign language game. Based on the premise that 2000 words equals 60 percent of a foreign language, Sixty Vocab is aiming to make learning essential vocabulary fun. The games teach the words most commonly used in conversation and applies time-based discipline — the faster you guess the word, the more rapidly you move on to the next one. Bridging the gap between your high school classes and a pricey foreign language program, Sixty Vocab is offering a unique option for those who want to learn a foreign language during their morning coffee or commute.
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
“We had to make Steve look like a blue-blooded man of great family wealth,” Mr. Corso said. “There’s a specific look, a definite visual that goes along with that.”
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
在《招魂》一举成功后， 埃德·沃伦和罗琳·沃伦夫妇又推出了其续集《招魂2》。 影片讲述了1977年发生在伦敦的一个真实故事——恩菲德招灵事件。
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
The housing slump has cut demand for iron ore, energy and other commodities. Higher global supplies have exacerbated the gap between supply and demand and pushed raw materials prices lower. This dynamic is not expected to change in the near term despite measures such as the interest rate cut in November.
But if the U.S. can avert that Washington-made crisis, the outlook for workers finding jobs is actually looking pretty good for next year. For one thing, the damage of superstorm Sandy will have to be repaired, meaning jobs in construction and retail. Businesses, meanwhile, which have held off investing and hiring because of uncertainty over the fiscal outlook, might finally open their wallets. That means more jobs, too.[qh]
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Anti-HIV drug repurposing against SARS-CoV-2
8. Flats are allowed on the red carpet – or are they?
Length-scale dependence of protein hydration-shell density
内森是少数几位在夜间拍卖会上积极出价的交易商之一。他在佳士得的拍卖会上代表一位客户以50.65万英镑拍下了查尔斯-安东尼·夸佩尔(Charles-Antoine Coypel)1737年的画作《阿米达宫的毁灭》(The Destruction of the Palace of Armida)，售价是预估价的两倍。
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
Some 695 million netizens used mobile phones to access the Internet in 2016, with a growth rate exceeding 10 percent for the third straight year, the report said. Smartphone-based Internet use accounted for 95.1 percent of all Internet users, up from 90.1 percent in 2015.
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
当晚的最高价来自唯一的一位欧洲电话出价人。此人以910万英镑购得约翰·康斯特布尔(John Constable)令人钦佩但很难让人喜爱的1824年纵向风景画《水闸》(The Lock)的1825年缩小版，这幅画从1855年起一直由一个英国家族私藏。
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In 2011 the owner of the tomb was identified as Liu Fei (169BC-127BC) the first king of Jiangdu an autonomous kingdom within the Han Dynasty according to China News.
The dollar value of China’s exports fell markedly more than expected last month and import growth more than halved, while revisions to November data erased what had appeared to be a long-hoped-for return to growth for outbound shipments.